The IMPACT Project – a Sino-Swedish collaboration to combat antibiotic resistance
The IMPACT project addressed factors that contribute to the development and spread of antibiotic resistance within a geographically defined area in China. This mixed methods project aimed to deliver a deeper understanding of the interaction and the overlap of antibiotic resistant bacteria between humans, animals and the environment. The project also investigated interventions that may lead to sustainable behavioural change for the purpose of informing national and international policies.
Contact
Anette Hulth
Phone: +46 10 205 23 95
The Sino-Swedish integrated multi-sectoral partnership for antibiotic resistance containment (IMPACT) was funded from 2014 to 2018 by the Swedish Research Council (VR) and National Natural Science Foundation of China (NSFC). The project brought together a wide range of expertise in Sweden and China in the area of antibiotic use and resistance.
- Impact Project summarypdf (2,7 MB)
The IMPACT research collaboration included the main areas:
- knowledge, attitudes and practice concerning human and animal antibiotic use
- distribution of resistant bacteria and genetic elements within the human, animal, environmental and health care sectors
- design, implementation and evaluation of strategies to promote rational use of antibiotics and to limit the spread of antibiotic resistance in all sectors.
Publications
- Rapid increase in occurrence of carbapenem-resistant Enterobacteriaceae in healthy rural residents in Shandong province, China, from 2015 to 2017 (pubmed.ncbi.nlm.nih.gov)
- Knowledge, attitudes and practices relating to antibiotic use and antibiotic resistance among backyard pig farmers in rural Shandong province, China (sciencedirect.com)
- Inter-host transmission of Carbapenemase-producing Escherichia coli among humans and backyard animals (ehp.niehs.nih.gov)
- Characterization of chromosome-mediated blaOXA-546-like in Shewanella xiamenensis isolated from pig wastewater (mdpi.com)
- Pattern of antibiotic prescribing and factors associated with it in eight village clinics in rural Shandong Province, China: a descriptive study (academic.oup.com)
- Evaluating dissemination mechanisms of antibiotic-resistant bacteria in rural environments in China by using CTX-M-producing Escherichia coli as an indicator (liebertpub.com)
- Dissemination of extended-spectrum β-lactamase-producing Escherichia coli carrying mcr-1 among multiple environmental sources in rural China and associated risk to human health (sciencedirect.com)
- Genomic analysis of Staphylococcus aureus along a pork production chain and in the community, Shandong Province, China (sciencedirect.com)
- Characterization of clinically relevant strains of extended-spectrum β-lactamase-producing Klebsiella pneumoniae occurring in environmental sources in a rural area of China by using whole-genome sequencing (dx.doi.org)
- Antibiotic use in people and pigs: a One Health survey of rural residents' knowledge, attitudes and practices in Shandong province, China (academic.oup.com)
- Mobile colistin resistance gene mcr-5 in porcine Aeromonas hydrophila (academic.oup.com)
- Occurrence of the mobile colistin resistance gene mcr-3 in Escherichia coli from household pigs in rural area (academic.oup.com)
- Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China and its potential for resistance development and ecological and human risk (sciencedirect.com)
- Presence and molecularcharacteristics of oxazolidinone resistance in staphylococci from householdanimals in rural China (dx.doi.org)
- Identical genotypes of community-associated MRSA (ST59) and livestock-associated MRSA (ST9) in humans and pigs in rural China (onlinelibrary.wiley.com)
- Study protocol for One Health data collections, analyses and intervention of the Sino-Swedish Integrated Multi-sectoral Partnership for Antibiotic Resistance Containment (IMPACT) (bmjopen.bmj.com)
- Occurrence of blaKPC-2, blaCTX-M and mcr-1 in Enterobacteriaceae from well water in rural China (aac.asm.org)
- Building bridges to operationalize One Health – a Sino-Swedish collaboration to tackle antibiotic resistance (sciencedirect.com)
Partner Organizations
- China Agricultural University
- Karolinska Institutet, Sweden
- Linköping University, Sweden
- National Food Agency, Sweden
- National Veterinary Institute, Sweden
- Public Health Agency of Sweden
- Shandong Academy of Agricultural Science, China
- Shandong Center for Disease Control and Prevention, China
- Shandong University, China
- Zhejiang University, China
Publication
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IMPACT – a Sino-Swedish collaboration to combat antibiotic resistance
Fact Sheet: Antibiotic resistance costs lives and money and threatens to undermine modern basic health care and advanced medicine. The scale of the challenge grows through globalization, with increased travel and worldwide food- and animal trade.
