European genomic surveillance of carbapenem and colistin resistant Enterobacteriaceae (EurGenCCRE)
EurGen-Net is an ECDC funded project aiming at establishing a European network for surveillance of antibiotic resistance by whole genome sequencing.
The network is coordinated by a consortium including the partners Karolinska University Laboratory and the EuCAST development laboratory in Växjö and led by the PHAS.
The project is based on the previously performed study, EuSCAPE, and it includes repeated, structured multi-centre molecular epidemiological survey of carbapenem- and/or colistin-resistant K. pneumoniae and E. coli among patients seeking hospital care. The overarching public health objective is to determine the occurrence, geographic distribution and the population dynamics of high-risk Enterobacteriaceae clones, and transmissible resistance/genetic-elements of critical public health importance in Europe.
Before the structured survey, capacity building efforts such as laboratory training workshops and the performance of an external quality assessment program (EQA) will take place within the network. This will ensure that harmonized methods are used for the genetic- and phenotypic confirmation of colistin and carbapenem resistance. All isolates collected in the structured survey will be whole genome sequenced either at a central facility or at the national level. The analysis of the whole genome sequences will enable in depth molecular epidemiology studies identifying high-risk clones and transmissible resistance elements.