IMPACT – a Sino-Swedish collaboration to combat antibiotic resistance
The IMPACT project addresses factors that contribute to the development and spread of antibiotic resistance within a geographically defined area in China. The project has a holistic approach and recent technical advances within molecular biology permit new questions to be asked.
Phone: +46 10 205 23 95
The Sino-Swedish integrated multi-sectoral partnership for antibiotic resistance containment (IMPACT) was funded from 2014 to 2018 by the Swedish Research Council (VR) and National Natural Science Foundation of China (NSFC). The project brings together a wide range of expertise in Sweden and China in the area of antibiotic use and resistance.
The IMPACT research collaboration includes the main areas:
- knowledge, attitudes and practice concerning human and animal antibiotic use
- distribution of resistant bacteria and genetic elements within the human, animal, environmental and health care sectors
- design, implementation and evaluation of strategies to promote rational use of antibiotics and to limit the spread of antibiotic resistance in all sectors.
Shen L, Dyar OJ, Sun Q, Wei X, Yang D, Sun C, et al. The effectiveness of an educational intervention on knowledge, attitudes and reported practices on antibiotic use in humans and pigs: a quasi-experimental study in twelve villages in Shandong province, China. Int J Environ Res Public Health 2021;18(4)1940.
Dyar OJ, Yang D, Yin J, Sun Q, Stålsby Lundborg C. Variations in antibiotic prescribing among village doctors in a rural region of Shandong province, China: a cross-sectional analysis of prescriptions. BMJ Open 2020 Jun 1;10(6):e036703.
- Dyar O, Zhang T, Yang P, Sun M, Sun C, Yin J, et al. Knowledge, attitudes and practices relating to antibiotic use and antibiotic resistance among backyard pig farmers in rural Shandong province, China. Prev Vet Med 2020;175.
- Li J, Bi Z, Ma S, Chen B, Cai C, He J, et al. Inter-host transmission of Carbapenemase-producing Escherichia coli among humans and backyard animals. Environ Health Perspect 2019 Oct;127(10):107009.
- Zou H, Zhou Z, Xia H, Zhao Q, Li X. Characterization of chromosome-mediated blaOXA-546-like in Shewanella xiamenensis isolated from pig wastewater. Int J Environ Res Public Health 2019;16(19), 3768.
- Yin J, Dyar OJ, Sun Q, Yang P, Yang D, Marrone G, et al. Pattern of antibiotic prescribing and factors associated with it in eight village clinics in rural Shandong Province, China: a descriptive study. Trans R Soc Trop Med Hyg 2019 July 11.
- Zou H, Zheng B, Sun M, Ottoson J, Li Y, Berglund B, et al. Evaluating dissemination mechanisms of antibiotic-resistant bacteria in rural environments in China by using CTX-M-producing Escherichia coli as an indicator. Microb Drug Resist 2019 Sep 25(7):975-984.
- Ji X, Zheng B, Berglund B, Zou H, Sun Q, Chi X, et al. Dissemination of extended-spectrum β-lactamase-producing Escherichia coli carrying mcr-1 among multiple environmental sources in rural China and associated risk to human health. Environ Pollut 2019 Aug 251:619-627.
- Sun C, Chen B, Hulth A, Schwarz S, Ji X, Nilsson LE, et al. Genomic analysis of Staphylococcus aureus along a pork production chain and in the community, Shandong Province, China. Int Journal Antimicrob Agents 2019 Jul 54(1):8-15.
- Chi X, Berglund B, Zou H, Zheng B, Börjesson S, Ji X, et al. Characterizationof clinically relevant strains of extended-spectrum β-lactamase-producing Klebsiella pneumoniae occurring in environmental sources in a rural area of China by using whole-genome sequencing. Front Microbiol 2019 Feb 12;10:211.
- Dyar OJ, Yin J, Ding L, Wikander K, Zhang T, Sun C, et al. Antibiotic use in people and pigs: a One Health survey of rural residents' knowledge, attitudes and practices in Shandong province, China. J Antimicrob Chemother 2018 Oct 1;73(10):2893-2899.
- Ma S, Sun C, Hulth A, Li J, Nilsson LE, Zhou Y, et al. Mobile colistin resistance gene mcr-5 in porcine Aeromonas hydrophila. J Antimicrob Chemother 2018 Jul 1;73(7):1777-1780.
- Li J, Hulth A, Nilsson LE, Börjesson S, Chen B, Bi Z, et al. Occurrence of the mobile colistin resistance gene mcr-3 in Escherichia coli from household pigs in rural area. J Antimicrob Chemother 2018 Jun 1;73(6):1721-1723.
- Hanna N, Sun P, Sun Q, Li X, Yang X, Ji X, et al. Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China and its potential for resistance development and ecological and human risk. Environ Int 2018 May;114:131-142.
- Sun C, Zhang P, Ji X, Fan R, Chen B, Wang Y, et al. Presence and molecularcharacteristics of oxazolidinone resistance in staphylococci from householdanimals in rural China. J Antimicrob Chemother 2018 May 1;73(5):1194-1200.
- Bi Z, Sun C, Börjesson S, Chen B, Ji X, Berglund B, et al. Identical genotypes of community-associated MRSA (ST59) and livestock-associated MRSA (ST9) in humans and pigs in rural China. Zoonoses Public Health 2018 May 65(3):367-371.
- Sun Q, Wang Y, Hulth A, Xiao Y, Nilsson LE, Li X, et al. Study protocol for One Health data collections, analyses and intervention of the Sino-Swedish Integrated Multi-sectoral Partnership for Antibiotic Resistance Containment (IMPACT). BMJ Open 2018 Jan 21;8(1):e017832.
- Sun P, Bi Z, Nilsson M, Zheng B, Berglund B, Stålsby Lundborg C, et al. Occurrence of blaKPC-2, blaCTX-M and mcr-1 in Enterobacteriaceae from well water in rural China. Antimicrob Agents Chemother 2017 Mar 24;61(4).
- Cars O, Xiao Y, Stålsby Lundborg C, Nilsson LE, Shen J, Sun Q, et al. Building bridges to operationalize One Health – a Sino-Swedish collaboration to tackle antibiotic resistance. One Health 2016 Sep 17;2:139-143.
- Factsheet (Chinese) (pdf)
- Factsheet (English) (pdf)
- China Agricultural University
- Karolinska Institutet, Sweden
- Linköping University, Sweden
- National Food Agency, Sweden
- National Veterinary Institute, Sweden
- Public Health Agency of Sweden
- Shandong Academy of Agricultural Science, China
- Shandong Center for Disease Control and Prevention, China
- Shandong University, China
- Zhejiang University, China